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LID/HID (lmw slp and hmw slp interacting domains) from C. difficile (R7404 strain)

Analyse LID/HID (lmw slp and hmw slp interacting domains) from C. difficile (R7404… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7ACW
Type
protein
Length
214 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
S-layer protein
EC
3.5.1.28
UniProt
Q9AEM2
Pockets
1 · best druggability 0.53

Structure

x-ray diffraction · 4 distinct chains · 46% helix, 26% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AS-layer protein (EC 3.5.1.28)protein6935% helix, 30% strandQ9AEM2
BS-layer protein (EC 3.5.1.28)protein3969% helix, 18% strandQ9AEM2
CS-layer protein (EC 3.5.1.28)protein7034% helix, 30% strandQ9AEM2
DS-layer protein (EC 3.5.1.28)protein3667% helix, 19% strandQ9AEM2

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11460.530.8129empty

Interfaces

4 interfaces between chains.

  • A–B · 1754 Ų buried · 25 hydrogen bonds · protein-protein
  • C–D · 1734 Ų buried · 28 hydrogen bonds · protein-protein
  • A–C · 326 Ų buried · 2 hydrogen bonds · protein-protein
  • A–D · 110 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

  • 7ACW · LID/HID (LMW SLP and HMW SLP interacting domains) from C. difficile (R7404 strain) · the same entry in another collection · chain A against A, TM-score 1.00

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