Research workbench
SLPL/HID (lmw slp complex with hmw slp interacting domain - hid) from C. difficile (R7404 strain)
Analyse SLPL/HID (lmw slp complex with hmw slp interacting domain - hid) from C.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ACV
- Type
- protein
- Length
- 461 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lmw slp; Hid - interacting domain of slp hmw
- EC
- 3.5.1.28
- UniProt
- Q9AEM2
- Pockets
- 5 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lmw slp (EC 3.5.1.28) | protein | 307 | 28% helix, 30% strand | Q9AEM2 |
| B | Lmw slp (EC 3.5.1.28) | protein | 127 | 40% helix, 29% strand | Q9AEM2 |
| C | Hid - interacting domain of slp hmw (EC 3.5.1.28) | protein | 27 | 59% helix, 19% strand | Q9AEM2 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.44 | 0.75 | 25 | empty |
| 2 | 83 | 0.36 | 0.75 | 15 | empty |
| 3 | 88 | 0.35 | 0.75 | 29 | empty |
| 4 | 61 | 0.34 | 0.77 | 16 | empty |
| 5 | 58 | 0.28 | 0.74 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1576 Ų buried · 24 hydrogen bonds · protein-protein
- A–B · 564 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7ACV · SLPL/HID (LMW SLP complex with HMW SLP interacting domain - HID) from C. difficile (R7404… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9AEM2
- Elsewhere: RCSB PDB 7ACV · PDBe 7ACV · UniProt Q9AEM2
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