Crystal structure of the drosophila mago nashi-Y14 complex

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 35% strand (DSSP).

Ligands and binding sites

• SR · Strontium ion · metal · chains A
• BME · Beta-mercaptoethanol · additive · 2 copies · chains A, B
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1209 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (additive adduct).

Compared structures

• 1OO0 · Crystal structure of the Drosophila Mago nashi-Y14 complex · the same entry in another collection · chain A against A, TM-score 1.00
• Q9V535 · AlphaFold monomer V2.0 prediction for RNA-binding protein 8A (Q9V535) · a predicted model of the same protein · chain B against A, TM-score 0.97
• P49028 · AlphaFold monomer V2.0 prediction for protein mago nashi (P49028) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P49028
• Every structure of UniProt Q9V535
• Elsewhere: RCSB PDB 1OO0 · PDBe 1OO0 · UniProt P49028 · UniProt Q9V535