Research workbench
Crystal structure of the escherichia COLI toxin-antitoxin system hipbst (hipt D233Q)
Analyse Crystal structure of the escherichia COLI toxin-antitoxin system hipbst (hipt… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AB5
- Type
- protein
- Length
- 1,015 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Predicted transcriptional regulator, xre family; COUPLE_HIPA domain-containing protein…
- UniProt
- B7UL98, B7UL97, B7UL96
- Pockets
- 14 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Predicted transcriptional regulator, xre family | protein | 70 | 64% helix, 11% strand | B7UL98 |
| B, E | COUPLE_HIPA domain-containing protein | protein | 100 | 20% helix, 31% strand | B7UL97 |
| C | HIPA_C domain-containing protein | protein | 338 | 39% helix, 13% strand | B7UL96 |
| F | HIPA_C domain-containing protein | protein | 337 | 38% helix, 12% strand | B7UL96 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.84 | 0.91 | 42 | empty |
| 2 | 686 | 0.81 | 0.85 | 73 | empty |
| 3 | 344 | 0.67 | 0.81 | 55 | empty |
| 4 | 255 | 0.59 | 0.79 | 48 | empty |
| 5 | 303 | 0.52 | 0.74 | 42 | empty |
Interfaces
7 interfaces between chains.
- A–D · 1416 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 1351 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 1339 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 531 Ų buried · 5 hydrogen bonds · protein-protein
- D–F · 524 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7AB5 · Crystal structure of the Escherichia coli toxin-antitoxin system HipBST (HipT D233Q) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B7UL98
- Every structure of UniProt B7UL97
- Every structure of UniProt B7UL96
- Elsewhere: RCSB PDB 7AB5 · PDBe 7AB5 · UniProt B7UL98 · UniProt B7UL97 · UniProt B7UL96
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