Research workbench
Structure of scoc PT13/PT15 lir motif bound to GABARAPL1
Analyse Structure of scoc PT13/PT15 lir motif bound to GABARAPL1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AA9
- Type
- protein
- Length
- 758 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid receptor-associated protein-like 1; PT13/PT15 scoc lir
- UniProt
- Q9H0R8
- Pockets
- 5 · best druggability 0.54
Structure
x-ray diffraction · 5 distinct chains · 31% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, G, K | Gamma-aminobutyric acid receptor-associated protein-like 1 | protein | 117 | 33% helix, 22% strand | Q9H0R8 |
| B, H, J | PT13/PT15 scoc lir | protein | 9 | 0% helix, 22% strand | — |
| C | Gamma-aminobutyric acid receptor-associated protein-like 1 | protein | 118 | 33% helix, 22% strand | Q9H0R8 |
| D, F, L | PT13/PT15 scoc lir | protein | 10 | 0% helix, 20% strand | — |
| I | Gamma-aminobutyric acid receptor-associated protein-like 1 | protein | 115 | 33% helix, 21% strand | Q9H0R8 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.54 | 0.75 | 33 | empty |
| 2 | 241 | 0.52 | 0.76 | 34 | empty |
| 3 | 157 | 0.43 | 0.75 | 26 | empty |
| 4 | 91 | 0.35 | 0.75 | 16 | empty |
| 5 | 51 | 0.27 | 0.74 | 11 | empty |
Interfaces
19 interfaces between chains.
- K–L · 644 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 641 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 639 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 633 Ų buried · 4 hydrogen bonds · protein-protein
- I–J · 631 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (phosphorylation).
Compared structures
- 7AA9 · Structure of SCOC pT13/pT15 LIR motif bound to GABARAPL1 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H0R8
- Elsewhere: RCSB PDB 7AA9 · PDBe 7AA9 · UniProt Q9H0R8
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