Research workbench
La crosse virus envelope glycoprotein gc W1066H mutant fusion domains in postfusion conformation
Analyse La crosse virus envelope glycoprotein gc W1066H mutant fusion domains in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7A57
- Type
- protein
- Length
- 1,322 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelopment polyprotein
- UniProt
- Q8JPR1
- Ligands
- NAG, FUC
- Pockets
- 16 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Envelopment polyprotein | protein | 437 | 5% helix, 53% strand | Q8JPR1 |
| B | Envelopment polyprotein | protein | 449 | 6% helix, 51% strand | Q8JPR1 |
| C | Envelopment polyprotein | protein | 436 | 5% helix, 53% strand | Q8JPR1 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, C, B
- FUC · alpha-L-fucopyranose · sugar · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1016 | 0.88 | 0.90 | 98 | empty |
| 2 | 467 | 0.81 | 0.89 | 61 | empty |
| 3 | 68 | 0.74 | 0.99 | 15 | empty |
| 4 | 933 | 0.72 | 0.77 | 101 | empty |
| 5 | 151 | 0.70 | 0.89 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–C · 3082 Ų buried · 40 hydrogen bonds · protein-protein
- B–C · 3039 Ų buried · 42 hydrogen bonds · protein-protein
- A–B · 3003 Ų buried · 38 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 30 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
- 7A57 · La Crosse Virus Envelope Glycoprotein Gc W1066H Mutant Fusion Domains in Postfusion… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8JPR1
- Elsewhere: RCSB PDB 7A57 · PDBe 7A57 · UniProt Q8JPR1
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