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Crystal structure of the C-src SH3 domain mutant V111L-N113S-T114S at pH 7.0

Analyse Crystal structure of the C-src SH3 domain mutant V111L-N113S-T114S at pH 7.0 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7A35
Type: protein
Length: 120 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase src
EC: 2.7.10.2
UniProt: P00523
Ligands: SO4
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2)	protein	60	5% helix, 42% strand	P00523

Ligands and binding sites

SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.37	0.74	23	empty

Interfaces

1 interface between chains.

A–B · 325 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7A35 · Crystal structure of the c-Src SH3 domain mutant V111L-N113S-T114S at pH 7.0 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00523
Elsewhere: RCSB PDB 7A35 · PDBe 7A35 · UniProt P00523

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