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Structure of SARS-cov-2 main protease bound to fusidic acid.

Analyse Structure of SARS-cov-2 main protease bound to fusidic acid. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7A1U
Type: protein
Length: 305 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase
EC: 3.4.22.69
UniProt: P0DTD1
Ligands: FUA
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.69)	protein	305	26% helix, 29% strand	P0DTD1

Ligands and binding sites

FUA · Fusidic acid · ligand · chains A
DMS · Dimethyl sulfoxide · additive · 5 copies · chains A
IMD · Imidazole · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.52	0.87	16	DMS
2	166	0.49	0.77	26	FUA, DMS, IMD
3	78	0.36	0.76	18	empty

Compared structures

7A1U · Structure of SARS-CoV-2 Main Protease bound to Fusidic Acid. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTD1
Elsewhere: RCSB PDB 7A1U · PDBe 7A1U · UniProt P0DTD1

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