Research workbench
Structure of TSC1 ntd and linker domain
Analyse Structure of TSC1 ntd and linker domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7A0N
- Type
- protein
- Length
- 1,551 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized PROTEIN,UNCHARACTERIZED protein
- UniProt
- G0S5K3
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized PROTEIN,UNCHARACTERIZED protein | protein | 393 | 74% helix, 1% strand | G0S5K3 |
| B | Uncharacterized PROTEIN,UNCHARACTERIZED protein | protein | 392 | 72% helix, 1% strand | G0S5K3 |
| C | Uncharacterized PROTEIN,UNCHARACTERIZED protein | protein | 380 | 73% helix, 1% strand | G0S5K3 |
| D | Uncharacterized PROTEIN,UNCHARACTERIZED protein | protein | 386 | 75% helix, 1% strand | G0S5K3 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 580 | 0.74 | 0.81 | 70 | empty |
| 2 | 547 | 0.71 | 0.80 | 52 | empty |
| 3 | 402 | 0.67 | 0.79 | 41 | empty |
| 4 | 411 | 0.64 | 0.78 | 47 | empty |
| 5 | 322 | 0.63 | 0.79 | 46 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1752 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1028 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1021 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 28 modified (engineered).
Compared structures
- 7A0N · Structure of TSC1 NTD and linker domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S5K3
- Elsewhere: RCSB PDB 7A0N · PDBe 7A0N · UniProt G0S5K3
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