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Crystal structure of E. COLI RNA helicase hrpa

Analyse Crystal structure of E. COLI RNA helicase hrpa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZWX
Type: protein
Length: 736 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase hrpa
EC: 3.6.4.13
UniProt: P43329
Pockets: 8 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase hrpa (EC 3.6.4.13)	protein	736	44% helix, 19% strand	P43329

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	935	0.80	0.82	90	empty
2	63	0.68	0.94	17	empty
3	396	0.62	0.77	38	empty
4	214	0.56	0.79	34	empty
5	282	0.56	0.76	27	empty

Modifications

Observed in the structure: 14 modified (engineered).

Compared structures

6ZWX · Crystal structure of E. coli RNA helicase HrpA · the same entry in another collection · chain A against A, TM-score 1.00
P43329 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase hrpa (P43329) · a predicted model of the same protein · chain A against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43329
Elsewhere: RCSB PDB 6ZWX · PDBe 6ZWX · UniProt P43329

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