Research workbench

Connectase MJ0548 from methanocaldococcus jannaschii

Analyse Connectase MJ0548 from methanocaldococcus jannaschii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZVZ
Type: protein
Length: 1,178 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Connectase MJ0548
UniProt: Q57968
Pockets: 14 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Connectase MJ0548	protein	294	30% helix, 37% strand	Q57968
C, D	Connectase MJ0548	protein	295	31% helix, 38% strand	Q57968

Pockets

14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1031	0.74	0.77	85	empty
2	585	0.71	0.79	71	empty
3	294	0.54	0.75	30	empty
4	260	0.49	0.74	29	empty
5	102	0.43	0.79	16	empty

Interfaces

6 interfaces between chains.

A–D · 454 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 450 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 284 Å² buried · 0 hydrogen bonds · protein-protein
C–D · 249 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 194 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6ZVZ · Connectase MJ0548 from Methanocaldococcus jannaschii · the same entry in another collection · chain A against A, TM-score 1.00
Q57968 · AlphaFold monomer V2.0 prediction for uncharacterized protein MJ0548 (Q57968) · a predicted model of the same protein · chain C against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57968
Elsewhere: RCSB PDB 6ZVZ · PDBe 6ZVZ · UniProt Q57968

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.