Research workbench
Crystal structure of citrate synthase (glta) from pseudomonas aeruginosa
Analyse Crystal structure of citrate synthase (glta) from pseudomonas aeruginosa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZU0
- Type
- protein
- Length
- 2,543 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Citrate synthase
- EC
- 2.3.3.16
- UniProt
- P14165
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 6 distinct chains · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Citrate synthase (EC 2.3.3.16) | protein | 425 | 54% helix, 10% strand | P14165 |
| B | Citrate synthase (EC 2.3.3.16) | protein | 424 | 54% helix, 10% strand | P14165 |
| C | Citrate synthase (EC 2.3.3.16) | protein | 426 | 53% helix, 10% strand | P14165 |
| D | Citrate synthase (EC 2.3.3.16) | protein | 424 | 53% helix, 10% strand | P14165 |
| E | Citrate synthase (EC 2.3.3.16) | protein | 422 | 54% helix, 10% strand | P14165 |
| F | Citrate synthase (EC 2.3.3.16) | protein | 422 | 55% helix, 9% strand | P14165 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.75 | 0.86 | 50 | empty |
| 2 | 654 | 0.73 | 0.80 | 69 | empty |
| 3 | 701 | 0.72 | 0.78 | 62 | empty |
| 4 | 622 | 0.72 | 0.79 | 68 | empty |
| 5 | 662 | 0.71 | 0.78 | 64 | empty |
Interfaces
12 interfaces between chains.
- A–B · 6081 Ų buried · 100 hydrogen bonds · protein-protein
- C–D · 6011 Ų buried · 102 hydrogen bonds · protein-protein
- E–F · 5832 Ų buried · 93 hydrogen bonds · protein-protein
- B–C · 404 Ų buried · 6 hydrogen bonds · protein-protein
- C–F · 398 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6ZU0 · Crystal structure of citrate synthase (GltA) from Pseudomonas aeruginosa · the same entry in another collection · chain F against F, TM-score 1.00
- P14165 · AlphaFold monomer V2.0 prediction for citrate synthase (P14165) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14165
- Elsewhere: RCSB PDB 6ZU0 · PDBe 6ZU0 · UniProt P14165
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.