Research workbench
Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8 groove, and TM1/TM2 groove of the fully induced acrb T protomer
Analyse Fusidic acid binding to the allosteric deep transmembrane domain binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZOD
- Type
- protein
- Length
- 3,391 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31224
- Ligands
- FUA, D10, PTY, 8K6, D12, SO4
Structure
x-ray diffraction · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1033 | — | P31224 |
| B | — | protein | 1020 | — | P31224 |
| C | — | protein | 1032 | — | P31224 |
| D | — | protein | 154 | — | — |
| E | — | protein | 152 | — | — |
Ligands and binding sites
- FUA · Fusidic acid · ligand · 4 copies · chains A, B
- D10 · Decane · ligand · 2 copies · chains A, B
- PTY · Phosphatidylethanolamine · ligand · 2 copies · chains B, C
- 8K6 · Octadecane · ligand · chains B
- D12 · Dodecane · ligand · chains C
- SO4 · Sulfate ion · ion · 5 copies · chains A, B, C
- EDO · 1,2-ethanediol · additive · 15 copies · chains A, B, C, D
- LMT · Dodecyl-beta-D-maltoside · additive · 7 copies · chains A, B, C
- GOL · Glycerol · additive · 2 copies · chains A, C, B
- PGE · Triethylene glycol · additive · chains B
- HEX · Hexane · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6ZOD · Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8… · the same entry in another collection · chain E against E, TM-score 1.00
- P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31224
- Elsewhere: RCSB PDB 6ZOD · PDBe 6ZOD · UniProt P31224
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