Research workbench
Maeb pta domain R535A mutant
Analyse Maeb pta domain R535A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZNR
- Type
- protein
- Length
- 2,031 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Malate dehydrogenase
- EC
- 1.1.1.40
- UniProt
- Q6MM15
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, F, E | Malate dehydrogenase (EC 1.1.1.40) | protein | 338 | 49% helix, 17% strand | Q6MM15 |
| D | Malate dehydrogenase (EC 1.1.1.40) | protein | 340 | 49% helix, 16% strand | Q6MM15 |
| C | Malate dehydrogenase (EC 1.1.1.40) | protein | 339 | 49% helix, 17% strand | Q6MM15 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1191 | 0.76 | 0.78 | 108 | empty |
| 2 | 246 | 0.73 | 0.87 | 24 | empty |
| 3 | 803 | 0.72 | 0.77 | 74 | empty |
| 4 | 280 | 0.70 | 0.84 | 26 | empty |
| 5 | 287 | 0.70 | 0.84 | 26 | empty |
Interfaces
12 interfaces between chains.
- D–C · 1711 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1692 Ų buried · 13 hydrogen bonds · protein-protein
- F–E · 1672 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 326 Ų buried · 0 hydrogen bonds · protein-protein
- E–C · 315 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6ZNR · MaeB PTA domain R535A mutant · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6MM15
- Elsewhere: RCSB PDB 6ZNR · PDBe 6ZNR · UniProt Q6MM15
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