Research workbench
Maeb malic enzyme domain apoprotein
Analyse Maeb malic enzyme domain apoprotein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZN4
- Type
- protein
- Length
- 814 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NADP-dependent malate DEHYDROGENASE,MALATE dehydrogenase
- EC
- 1.1.1.40
- UniProt
- Q6MM14, Q6MM15
- Ligands
- MG
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NADP-dependent malate DEHYDROGENASE,MALATE dehydrogenase (EC 1.1.1.40) | protein | 406 | 47% helix, 13% strand | Q6MM14, Q6MM15 |
| B | NADP-dependent malate DEHYDROGENASE,MALATE dehydrogenase (EC 1.1.1.40) | protein | 408 | 46% helix, 13% strand | Q6MM14, Q6MM15 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 644 | 0.75 | 0.81 | 56 | empty |
| 2 | 688 | 0.73 | 0.79 | 52 | MG |
| 3 | 64 | 0.41 | 0.80 | 17 | empty |
| 4 | 109 | 0.40 | 0.76 | 18 | empty |
| 5 | 65 | 0.39 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 4266 Ų buried · 50 hydrogen bonds · protein-protein
Compared structures
- 6ZN4 · MaeB malic enzyme domain apoprotein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6MM14
- Every structure of UniProt Q6MM15
- Elsewhere: RCSB PDB 6ZN4 · PDBe 6ZN4 · UniProt Q6MM14 · UniProt Q6MM15
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