Research workbench
Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding.
Analyse Partial structure of tyrosine hydroxylase in complex with dopamine showing the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZN2
- Type
- protein
- Length
- 1,412 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine 3-monooxygenase; Ser-leu-ile-glu-asp-ala-arg-lys-glu-arg-glu-ala-ala-val…
- EC
- 1.14.16.2
- UniProt
- P07101
- Ligands
- LDP, FE
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 2 distinct chains · 51% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Tyrosine 3-monooxygenase (EC 1.14.16.2) | protein | 335 | 49% helix, 10% strand | P07101 |
| B, D, F, H | Ser-leu-ile-glu-asp-ala-arg-lys-glu-arg-glu-ala-ala-val- ala-ala-ala-ala | protein | 18 | 83% helix, 0% strand | — |
Ligands and binding sites
- LDP · L-dopamine · ligand · 4 copies · chains A, B, C, D, E, F, G, H
- FE · Fe (III) ion · metal · 4 copies · chains A, C, E, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1141 | 0.88 | 0.90 | 148 | LDP |
| 2 | 835 | 0.84 | 0.86 | 89 | LDP, FE |
| 3 | 765 | 0.83 | 0.86 | 78 | LDP, FE |
| 4 | 1004 | 0.83 | 0.84 | 108 | empty |
| 5 | 756 | 0.82 | 0.86 | 72 | LDP, FE |
Interfaces
10 interfaces between chains.
- A–E · 1850 Ų buried · 26 hydrogen bonds · protein-protein
- C–G · 1841 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 630 Ų buried · 4 hydrogen bonds · protein-protein
- E–F · 630 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 626 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6ZN2 · Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic… · the same entry in another collection · chain H against H, TM-score 1.00
- P07101 · AlphaFold monomer V2.0 prediction for tyrosine 3-monooxygenase (P07101) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07101
- Elsewhere: RCSB PDB 6ZN2 · PDBe 6ZN2 · UniProt P07101
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