Research workbench
Coxsackievirus B4 strain E2
Analyse Coxsackievirus B4 strain E2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZMS
- Type
- protein
- Length
- 818 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- Q8V639
- Pockets
- 10 · best druggability 0.74
Structure
electron microscopy · 4 distinct chains · 4% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 271 | 6% helix, 27% strand | Q8V639 |
| B | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 252 | 4% helix, 33% strand | Q8V639 |
| C | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 238 | 3% helix, 30% strand | Q8V639 |
| D | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 57 | 0% helix, 16% strand | Q8V639 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 300 | 0.74 | 0.86 | 45 | empty |
| 2 | 367 | 0.57 | 0.75 | 48 | empty |
| 3 | 95 | 0.44 | 0.79 | 27 | empty |
| 4 | 69 | 0.42 | 0.81 | 19 | empty |
| 5 | 131 | 0.38 | 0.73 | 19 | empty |
Interfaces
6 interfaces between chains.
- A–C · 4322 Ų buried · 68 hydrogen bonds · protein-protein
- A–B · 2142 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 1689 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 1300 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 925 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6ZMS · Coxsackievirus B4 strain E2 · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8V639
- Elsewhere: RCSB PDB 6ZMS · PDBe 6ZMS · UniProt Q8V639
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