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Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor ATP
Analyse Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZJD
- Type
- protein
- Length
- 214 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP:AMP phosphotransferase AK3, mitochondrial
- EC
- 2.7.4.10
- UniProt
- Q9UIJ7
- Ligands
- ATP, MG, NA, CL
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) | protein | 214 | 47% helix, 18% strand | Q9UIJ7 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.55 | 0.77 | 35 | ATP, MG, CL |
| 2 | 140 | 0.47 | 0.77 | 18 | empty |
Compared structures
- 6ZJD · Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor ATP · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UIJ7 · AlphaFold monomer V2.0 prediction for GTP:AMP phosphotransferase AK3, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIJ7
- Elsewhere: RCSB PDB 6ZJD · PDBe 6ZJD · UniProt Q9UIJ7
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