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The IRAK3 pseudokinase domain bound to atpgammas

Analyse The IRAK3 pseudokinase domain bound to atpgammas in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZIW
Type: protein
Length: 267 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-1 receptor-associated kinase 3
EC: 2.7.11.1
UniProt: Q9Y616
Ligands: AGS, SO4
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
I	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)	protein	267	47% helix, 16% strand	Q9Y616

Ligands and binding sites

AGS · Phosphothiophosphoric acid-adenylate ester · ligand · chains I
SO4 · Sulfate ion · ion · 2 copies · chains I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	329	0.61	0.78	34	AGS

Compared structures

6ZIW · The IRAK3 Pseudokinase Domain Bound To ATPgammaS · the same entry in another collection · chain I against I, TM-score 1.00
Q9Y616 · AlphaFold monomer V2.0 prediction for interleukin-1 receptor- associated kinase 3 (Q9Y616) · a predicted model of the same protein · chain I against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y616
Elsewhere: RCSB PDB 6ZIW · PDBe 6ZIW · UniProt Q9Y616

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