Research workbench
Cryo-EM structure of escrt-III helical VPS24 filaments
Analyse Cryo-EM structure of escrt-III helical VPS24 filaments in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZH3
- Type
- protein
- Length
- 680 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vacuolar protein-sorting-associated protein 24
- UniProt
- P36095
- Pockets
- 7 · best druggability 0.35
Structure
electron microscopy · 1 distinct chain · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C, D | Vacuolar protein-sorting-associated protein 24 | protein | 170 | 78% helix, 0% strand | P36095 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.35 | 0.77 | 15 | empty |
| 2 | 74 | 0.33 | 0.75 | 15 | empty |
| 3 | 75 | 0.33 | 0.75 | 18 | empty |
| 4 | 80 | 0.32 | 0.74 | 14 | empty |
| 5 | 69 | 0.32 | 0.75 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–A · 3360 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 3352 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 53 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6ZH3 · Cryo-EM structure of ESCRT-III helical Vps24 filaments · the same entry in another collection · chain B against B, TM-score 1.00
- P36095 · AlphaFold monomer V2.0 prediction for vacuolar protein-sorting- associated protein 24… · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36095
- Elsewhere: RCSB PDB 6ZH3 · PDBe 6ZH3 · UniProt P36095
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