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Crystal structure of lanthanide-dependent alcohol dehydrogenase pedh from pseudomonas putida KT2440

Analyse Crystal structure of lanthanide-dependent alcohol dehydrogenase pedh from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZCW
Type: protein
Length: 562 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Quinoprotein ethanol dehydrogenase
EC: 1.1.2.8
UniProt: Q88JH0
Ligands: PQQ, PR
Pockets: 4 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Quinoprotein ethanol dehydrogenase (EC 1.1.2.8)	protein	562	7% helix, 41% strand	Q88JH0

Ligands and binding sites

PQQ · Pyrroloquinoline quinone · ligand · chains A
PR · Praseodymium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.79	0.98	34	PQQ
2	78	0.38	0.77	23	empty
3	61	0.32	0.76	18	empty
4	67	0.28	0.73	13	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6ZCW · Crystal structure of lanthanide-dependent alcohol dehydrogenase PedH from Pseudomonas… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q88JH0
Elsewhere: RCSB PDB 6ZCW · PDBe 6ZCW · UniProt Q88JH0

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