Research workbench
Merozoite surface protein 1 (msp-1) from plasmodium falciparum, alternative conformation 5
Analyse Merozoite surface protein 1 (msp-1) from plasmodium falciparum, alternative… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZBH
- Type
- protein
- Length
- 1,159 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Merozoite surface antigens; Merozoite surface protein-1; Merozoite surface protein 1
- UniProt
- Q25922, M1V901, M1VNZ6, C4PDY5
- Pockets
- 20 · best druggability 0.71
Structure
electron microscopy · 4 distinct chains · 79% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Merozoite surface antigens | protein | 562 | 78% helix, 1% strand | Q25922 |
| B | Merozoite surface antigens | protein | 112 | 74% helix, 1% strand | M1V901 |
| C | Merozoite surface protein-1 | protein | 284 | 77% helix, 1% strand | M1VNZ6 |
| D | Merozoite surface protein 1 | protein | 201 | 86% helix, 1% strand | C4PDY5 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.71 | 0.83 | 43 | empty |
| 2 | 169 | 0.66 | 0.86 | 31 | empty |
| 3 | 640 | 0.66 | 0.76 | 67 | empty |
| 4 | 480 | 0.64 | 0.77 | 39 | empty |
| 5 | 394 | 0.62 | 0.77 | 50 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2974 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 2248 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 2182 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1478 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 1000 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6ZBH · Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 5 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q25922
- Every structure of UniProt M1V901
- Every structure of UniProt M1VNZ6
- Every structure of UniProt C4PDY5
- Elsewhere: RCSB PDB 6ZBH · PDBe 6ZBH · UniProt Q25922 · UniProt M1V901 · UniProt M1VNZ6 · UniProt C4PDY5
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