Research workbench
Exo-beta-1,3-glucanase from moose rumen microbiome, active site mutant E167Q/E295Q
Analyse Exo-beta-1,3-glucanase from moose rumen microbiome, active site mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZB8
- Type
- protein
- Length
- 737 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Exo-beta-1,3-glucanase variant E167Q/E295Q
- EC
- 3.2.1.58
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Exo-beta-1,3-glucanase variant E167Q/E295Q (EC 3.2.1.58) | protein | 367 | 46% helix, 11% strand | — |
| B | Exo-beta-1,3-glucanase variant E167Q/E295Q (EC 3.2.1.58) | protein | 370 | 45% helix, 11% strand | — |
Ligands and binding sites
- 15P · Polyethylene glycol (N=34) · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.72 | 0.81 | 38 | 15P |
| 2 | 727 | 0.71 | 0.78 | 77 | 15P |
| 3 | 63 | 0.71 | 0.98 | 21 | empty |
| 4 | 261 | 0.59 | 0.79 | 33 | empty |
| 5 | 91 | 0.36 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1697 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 6ZB8 · Exo-beta-1,3-glucanase from moose rumen microbiome, active site mutant E167Q/E295Q · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6ZB8 · PDBe 6ZB8
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