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Structure of the mate family multidrug resistance transporter AQ_128 from aquifex aeolicus in the outward-facing state

Analyse Structure of the mate family multidrug resistance transporter AQ_128 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6Z71
Type: protein
Length: 842 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: AQ128
UniProt: O66528
Pockets: 7 · best druggability 0.89

Structure

x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	AQ128	protein	419	80% helix, 0% strand	O66528
B	AQ128	protein	423	78% helix, 0% strand	O66528

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1125	0.89	0.90	92	empty
2	1096	0.87	0.88	78	empty
3	1122	0.82	0.83	82	empty
4	93	0.46	0.80	23	empty
5	76	0.40	0.79	14	empty

Interfaces

1 interface between chains.

A–B · 785 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6Z71 · Structure of the MATE family multidrug resistance transporter Aq_128 from Aquifex… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O66528
Elsewhere: RCSB PDB 6Z71 · PDBe 6Z71 · UniProt O66528

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