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Arrangement of the matrix protein M1 in influenza A/HONG KONG/1/1968 vlps (HA,NA,M1,M2)

Analyse Arrangement of the matrix protein M1 in influenza A/HONG KONG/1/1968 vlps… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6Z5J
Type
protein
Length
942 residues
Chains
6
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Matrix protein 1
UniProt
F0TTD6
Pockets
9 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 68% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
E, F, D, C, B, AMatrix protein 1protein15768% helix, 0% strandF0TTD6

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
110160.820.83120empty
28440.760.8088empty
34130.730.8363empty
41050.620.8823empty
51450.550.8128empty

Interfaces

9 interfaces between chains.

  • E–F · 499 Ų buried · 3 hydrogen bonds · protein-protein
  • E–D · 492 Ų buried · 2 hydrogen bonds · protein-protein
  • C–B · 445 Ų buried · 2 hydrogen bonds · protein-protein
  • B–A · 382 Ų buried · 2 hydrogen bonds · protein-protein
  • D–B · 235 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

  • 6Z5J · Arrangement of the matrix protein M1 in influenza A/Hong Kong/1/1968 VLPs (HA,NA,M1,M2) · the same entry in another collection · chain E against E, TM-score 1.00

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