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Cryoem structure of horse SODIUM/PROTON exchanger NHE9 without C- terminal regulatory domain in an inward-facing conformation

Analyse Cryoem structure of horse SODIUM/PROTON exchanger NHE9 without C- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6Z3Z
Type: protein
Length: 769 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SODIUM/HYDROGEN exchanger
UniProt: F7B113
Pockets: 18 · best druggability 0.83

Structure

electron microscopy · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	SODIUM/HYDROGEN exchanger	protein	385	71% helix, 0% strand	F7B113
A	SODIUM/HYDROGEN exchanger	protein	384	73% helix, 0% strand	F7B113

Pockets

18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	764	0.83	0.85	80	empty
2	991	0.78	0.80	64	empty
3	952	0.78	0.80	68	empty
4	336	0.66	0.80	40	empty
5	56	0.64	0.94	16	empty

Interfaces

1 interface between chains.

B–A · 1926 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6Z3Z · CryoEM structure of horse sodium/proton exchanger NHE9 without C-terminal regulatory… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F7B113
Elsewhere: RCSB PDB 6Z3Z · PDBe 6Z3Z · UniProt F7B113

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