Research workbench
Structure of the danio rerio sas-6 coiled-coil domain
Analyse Structure of the danio rerio sas-6 coiled-coil domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Z26
- Type
- protein
- Length
- 403 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spindle assembly abnormal protein 6 homolog
- UniProt
- Q7ZVT3
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 4 distinct chains · 95% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spindle assembly abnormal protein 6 homolog | protein | 100 | 93% helix, 0% strand | Q7ZVT3 |
| B | Spindle assembly abnormal protein 6 homolog | protein | 103 | 96% helix, 0% strand | Q7ZVT3 |
| C | Spindle assembly abnormal protein 6 homolog | protein | 103 | 95% helix, 0% strand | Q7ZVT3 |
| D | Spindle assembly abnormal protein 6 homolog | protein | 97 | 96% helix, 0% strand | Q7ZVT3 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.34 | 0.74 | 16 | empty |
| 2 | 93 | 0.32 | 0.72 | 18 | empty |
Interfaces
4 interfaces between chains.
- B–C · 2498 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 2487 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 381 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 30 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified, 3 disulfide (engineered, disulfide).
Compared structures
- 6Z26 · Structure of the Danio rerio SAS-6 coiled-coil domain · the same entry in another collection · chain D against D, TM-score 1.00
- Q7ZVT3 · AlphaFold monomer V2.0 prediction for spindle assembly abnormal protein 6 homolog (Q7ZVT3) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7ZVT3
- Elsewhere: RCSB PDB 6Z26 · PDBe 6Z26 · UniProt Q7ZVT3
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