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Campylobacter jejuni serine protease htra

Analyse Campylobacter jejuni serine protease htra in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6Z05
Type: protein
Length: 5,208 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Degq family serine endoprotease
UniProt: A0A620LS18
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 15% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L	Degq family serine endoprotease	protein	434	15% helix, 29% strand	A0A620LS18

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1005	0.82	0.83	90	empty
2	928	0.79	0.81	64	empty
3	873	0.78	0.81	62	empty
4	859	0.77	0.81	65	empty
5	548	0.77	0.84	74	empty

Interfaces

24 interfaces between chains.

A–B · 1227 Å² buried · 14 hydrogen bonds · protein-protein
G–I · 1190 Å² buried · 11 hydrogen bonds · protein-protein
D–E · 1155 Å² buried · 9 hydrogen bonds · protein-protein
D–F · 1146 Å² buried · 11 hydrogen bonds · protein-protein
K–L · 1145 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6Z05 · Campylobacter jejuni serine protease HtrA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A620LS18
Elsewhere: RCSB PDB 6Z05 · PDBe 6Z05 · UniProt A0A620LS18

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