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Structure of S. pombe MEI2 RRM3 domain bound to RNA

Analyse Structure of S. pombe MEI2 RRM3 domain bound to RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6YYM
Type: protein + RNA
Length: 160 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Meiosis protein MEI2; RNA (5'-R(*GP*CP*UP*UP*UP*UP*UP*GP*UP*UP*CP*G)-3')
UniProt: P08965
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Meiosis protein MEI2	protein	148	23% helix, 24% strand	P08965
B	RNA (5'-R(GPCPUPUPUPUPUPGPUPUPCPG)-3')	rna	12	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.31	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 1228 Å² buried · 39 hydrogen bonds · protein-nucleic

Compared structures

6YYM · Structure of S. pombe Mei2 RRM3 domain bound to RNA · the same entry in another collection · chain A against A, TM-score 1.00
P08965 · AlphaFold monomer V2.0 prediction for meiosis protein MEI2 (P08965) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08965
Elsewhere: RCSB PDB 6YYM · PDBe 6YYM · UniProt P08965

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