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Structure of the chlamydomonas reinhardtii sas-6 coiled-coil domain, P2 crystal form

Analyse Structure of the chlamydomonas reinhardtii sas-6 coiled-coil domain, P2 crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6YRN
Type: protein
Length: 831 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centriole protein
UniProt: A9CQL4
Pockets: 15 · best druggability 0.67

Structure

x-ray diffraction · 8 distinct chains · 97% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Centriole protein	protein	107	98% helix, 0% strand	A9CQL4
B	Centriole protein	protein	101	97% helix, 0% strand	A9CQL4
C	Centriole protein	protein	101	98% helix, 0% strand	A9CQL4
D	Centriole protein	protein	111	98% helix, 0% strand	A9CQL4
E	Centriole protein	protein	107	98% helix, 0% strand	A9CQL4
F	Centriole protein	protein	106	97% helix, 0% strand	A9CQL4
G	Centriole protein	protein	93	94% helix, 0% strand	A9CQL4
H	Centriole protein	protein	105	98% helix, 0% strand	A9CQL4

Ligands and binding sites

PG4 · Tetraethylene glycol · additive · chains B, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	436	0.67	0.79	50	empty
2	585	0.64	0.75	54	PG4
3	445	0.57	0.74	44	empty
4	307	0.50	0.73	30	empty
5	115	0.47	0.79	22	empty

Interfaces

16 interfaces between chains.

A–D · 2911 Å² buried · 24 hydrogen bonds · protein-protein
B–C · 2811 Å² buried · 23 hydrogen bonds · protein-protein
E–F · 2786 Å² buried · 22 hydrogen bonds · protein-protein
G–H · 2470 Å² buried · 15 hydrogen bonds · protein-protein
A–E · 1070 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6YRN · Structure of the Chlamydomonas reinhardtii SAS-6 coiled-coil domain, P2 crystal form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9CQL4
Elsewhere: RCSB PDB 6YRN · PDBe 6YRN · UniProt A9CQL4

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