Research workbench
Crystal structure of the SYCE2-TEX12 delta-ctip complex in a 4:4 assembly
Analyse Crystal structure of the SYCE2-TEX12 delta-ctip complex in a 4:4 assembly in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6YQF
- Type
- protein
- Length
- 295 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Synaptonemal complex central element protein 2; Testis-expressed protein 12
- UniProt
- Q6PIF2, Q9BXU0
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 97% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Synaptonemal complex central element protein 2 | protein | 94 | 98% helix, 0% strand | Q6PIF2 |
| B | Synaptonemal complex central element protein 2 | protein | 90 | 98% helix, 0% strand | Q6PIF2 |
| C | Testis-expressed protein 12 | protein | 61 | 97% helix, 0% strand | Q9BXU0 |
| D | Testis-expressed protein 12 | protein | 50 | 96% helix, 0% strand | Q9BXU0 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 495 | 0.72 | 0.81 | 45 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1158 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 1059 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 1003 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 917 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 872 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6YQF · Crystal structure of the SYCE2-TEX12 delta-Ctip complex in a 4:4 assembly · the same entry in another collection · chain D against D, TM-score 1.00
- Q6PIF2 · AlphaFold monomer V2.0 prediction for synaptonemal complex central element protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.90
- Q9BXU0 · AlphaFold monomer V2.0 prediction for testis-expressed protein 12 (Q9BXU0) · a predicted model of the same protein · chain D against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PIF2
- Every structure of UniProt Q9BXU0
- Elsewhere: RCSB PDB 6YQF · PDBe 6YQF · UniProt Q6PIF2 · UniProt Q9BXU0
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