Research workbench
Crystal structure of HEL4, a soluble human vh antibody domain resistant to aggregation
Analyse Crystal structure of HEL4, a soluble human vh antibody domain resistant to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OHQ
- Type
- protein
- Length
- 239 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Immunoglobulin | protein | 120 | 5% helix, 51% strand | — |
| B | Immunoglobulin | protein | 119 | 5% helix, 55% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.61 | 0.89 | 27 | empty |
| 2 | 81 | 0.31 | 0.73 | 14 | empty |
| 3 | 53 | 0.27 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 970 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1OHQ · Crystal structure of HEL4, a soluble human VH antibody domain resistant to aggregation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1OHQ · PDBe 1OHQ
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