Research workbench
Cryo-EM structure of a bcsb pentamer in the context of an assembled bcs macrocomplex
Analyse Cryo-EM structure of a bcsb pentamer in the context of an assembled bcs… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6YG8
- Type
- protein
- Length
- 3,132 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterial cellulose secretion regulator bcsb
- UniProt
- A0A061KLG7
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 4 distinct chains · 15% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bacterial cellulose secretion regulator bcsb | protein | 643 | 15% helix, 38% strand | A0A061KLG7 |
| B, C | Bacterial cellulose secretion regulator bcsb | protein | 637 | 16% helix, 37% strand | A0A061KLG7 |
| D | Bacterial cellulose secretion regulator bcsb | protein | 639 | 14% helix, 35% strand | A0A061KLG7 |
| E | Bacterial cellulose secretion regulator bcsb | protein | 576 | 14% helix, 35% strand | A0A061KLG7 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 645 | 0.80 | 0.85 | 70 | empty |
| 2 | 585 | 0.78 | 0.84 | 48 | empty |
| 3 | 618 | 0.76 | 0.83 | 64 | empty |
| 4 | 703 | 0.76 | 0.81 | 116 | empty |
| 5 | 674 | 0.75 | 0.81 | 53 | empty |
Interfaces
7 interfaces between chains.
- B–D · 3491 Ų buried · 59 hydrogen bonds · protein-protein
- A–C · 3471 Ų buried · 55 hydrogen bonds · protein-protein
- A–B · 3449 Ų buried · 42 hydrogen bonds · protein-protein
- C–E · 3419 Ų buried · 54 hydrogen bonds · protein-protein
- A–E · 26 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6YG8 · Cryo-EM structure of a BcsB pentamer in the context of an assembled Bcs macrocomplex · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A061KLG7
- Elsewhere: RCSB PDB 6YG8 · PDBe 6YG8 · UniProt A0A061KLG7
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