Crystal structure of ampc from E. COLI with cyclic boronate 2

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• OK3 · (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid · ligand · 4 copies · chains A, B, C, D
• NA · Sodium ion · metal · chains A
• CL · Chloride ion · ion · 3 copies · chains A, B, D
• GOL · Glycerol · additive · 4 copies · chains B, A, C
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 3 copies · chains A, B, D
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 2 copies · chains A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6YEO · Crystal structure of AmpC from E. coli with cyclic boronate 2 · the same entry in another collection · chain D against D, TM-score 1.00
• P00811 · AlphaFold monomer V2.0 prediction for beta-lactamase (P00811) · a predicted model of the same protein · chain B against A, TM-score 1.00
• 1L2S · X-ray crystal structure of ampc beta-lactamase from E. COLI in complex with a… · a predicted model of the same protein · chain B against B, TM-score 1.00
• 1L2S · X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with a… · a predicted model of the same protein · chain B against B, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00811
• Elsewhere: RCSB PDB 6YEO · PDBe 6YEO · UniProt P00811