Research workbench
Crystal structure of whirlin PDZ3 in complex with myosin 15A C- terminal PDZ binding motif peptide
Analyse Crystal structure of whirlin PDZ3 in complex with myosin 15A C- terminal PDZ… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Y38
- Type
- protein
- Length
- 209 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Whirlin; Chains: C,D
- UniProt
- Q80VW5
- Pockets
- 1 · best druggability 0.36
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Whirlin | protein | 91 | 19% helix, 33% strand | Q80VW5 |
| B | Whirlin | protein | 92 | 20% helix, 33% strand | Q80VW5 |
| C, D | Chains: C,D | protein | 13 | 0% helix, 31% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.36 | 0.75 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–C · 667 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 653 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 439 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 306 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 290 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6Y38 · Crystal structure of Whirlin PDZ3 in complex with Myosin 15a C-terminal PDZ binding motif… · the same entry in another collection · chain A against A, TM-score 1.00
- Q80VW5 · AlphaFold monomer V2.0 prediction for whirlin (Q80VW5) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80VW5
- Elsewhere: RCSB PDB 6Y38 · PDBe 6Y38 · UniProt Q80VW5
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