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Crystal structure of the unmodified A.17 antibody Fab fragment - L47R mutant

Analyse Crystal structure of the unmodified A.17 antibody Fab fragment - L47R mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6Y1K
Type: protein
Length: 432 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab A.17 L47R mutant heavy chain; Fab A.17 L47R mutant light chain
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab A.17 L47R mutant heavy chain	protein	216	8% helix, 51% strand	—
L	Fab A.17 L47R mutant light chain	protein	216	4% helix, 49% strand	—

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	239	0.65	0.83	39	empty
2	566	0.61	0.74	70	empty
3	52	0.51	0.88	21	empty
4	123	0.44	0.77	27	empty

Interfaces

1 interface between chains.

H–L · 1826 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6Y1K · Crystal structure of the unmodified A.17 antibody FAB fragment - L47R mutant · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6Y1K · PDBe 6Y1K

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