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Complex of C-terminal domain of murine complement C3B with the HC3NB3 nanobody

Analyse Complex of C-terminal domain of murine complement C3B with the HC3NB3 nanobody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XZU
Type: protein
Length: 269 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nanobody HC3NB1; Complement C3
UniProt: P01027
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nanobody HC3NB1	protein	121	7% helix, 47% strand	—
B	Complement C3	protein	148	28% helix, 33% strand	P01027

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	374	0.64	0.78	39	empty
2	100	0.36	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 674 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6XZU · Complex of C-terminal domain of murine complement C3b with the hC3Nb3 nanobody · the same entry in another collection · chain A against A, TM-score 1.00
P01027 · AlphaFold monomer V2.0 prediction for complement C3 (P01027) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01027
Elsewhere: RCSB PDB 6XZU · PDBe 6XZU · UniProt P01027

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