Research workbench
Influenza C virus polymerase in complex with human ANP32A - subclass 1
Analyse Influenza C virus polymerase in complex with human ANP32A - subclass 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XZQ
- Type
- protein + RNA
- Length
- 3,511 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (5'- R(*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*GP*CP*CP*CP*UP*G)-3'); Polymerase…
- EC
- 3.1.-.-, 2.7.7.48
- UniProt
- Q9IMP5, Q9IMP4, Q9IMP3, P39687
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 8 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I | RNA (5'- R(*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*GP*CP*CP*CP*UP*G)-3') | rna | 19 | — | — |
| A | Polymerase acidic protein (EC 3.1.-.-) | protein | 696 | 44% helix, 15% strand | Q9IMP5 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 698 | 46% helix, 11% strand | Q9IMP4 |
| C | Polymerase basic protein 2 | protein | 772 | 37% helix, 17% strand | Q9IMP3 |
| D | Polymerase acidic protein (EC 3.1.-.-) | protein | 525 | 44% helix, 17% strand | Q9IMP5 |
| E | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 448 | 44% helix, 15% strand | Q9IMP4 |
| F | Polymerase basic protein 2 | protein | 195 | 35% helix, 13% strand | Q9IMP3 |
| G | Acidic leucine-rich nuclear phosphoprotein 32 family member a | protein | 158 | 20% helix, 8% strand | P39687 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 959 | 0.84 | 0.85 | 91 | empty |
| 2 | 895 | 0.83 | 0.85 | 87 | empty |
| 3 | 438 | 0.80 | 0.88 | 54 | empty |
| 4 | 545 | 0.80 | 0.86 | 60 | empty |
| 5 | 713 | 0.79 | 0.84 | 77 | empty |
Interfaces
17 interfaces between chains.
- A–B · 8527 Ų buried · 58 hydrogen bonds · protein-protein
- B–C · 7549 Ų buried · 46 hydrogen bonds · protein-protein
- D–E · 5863 Ų buried · 51 hydrogen bonds · protein-protein
- A–C · 2644 Ų buried · 17 hydrogen bonds · protein-protein
- I–A · 1208 Ų buried · 15 hydrogen bonds · protein-nucleic
Compared structures
- 6XZQ · Influenza C virus polymerase in complex with human ANP32A - Subclass 1 · the same entry in another collection · chain G against G, TM-score 1.00
- P39687 · AlphaFold monomer V2.0 prediction for acidic leucine-rich nuclear phosphoprotein 32… · a predicted model of the same protein · chain G against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9IMP5
- Every structure of UniProt Q9IMP4
- Every structure of UniProt Q9IMP3
- Every structure of UniProt P39687
- Elsewhere: RCSB PDB 6XZQ · PDBe 6XZQ · UniProt Q9IMP5 · UniProt Q9IMP4 · UniProt Q9IMP3 · UniProt P39687
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