Research workbench

Arabidopsis UV-B photoreceptor UVR8 mutant G101S W285A

Analyse Arabidopsis UV-B photoreceptor UVR8 mutant G101S W285A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XZN
Type: protein
Length: 728 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ultraviolet-B receptor UVR8
UniProt: Q9FN03
Pockets: 5 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ultraviolet-B receptor UVR8	protein	367	5% helix, 45% strand	Q9FN03
B	Ultraviolet-B receptor UVR8	protein	361	5% helix, 44% strand	Q9FN03

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B
PGE · Triethylene glycol · additive · 2 copies · chains B, A
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	242	0.83	0.95	37	GOL, PGE
2	470	0.76	0.85	49	PGE
3	444	0.75	0.85	45	PEG
4	302	0.66	0.82	51	empty
5	203	0.63	0.83	27	empty

Interfaces

1 interface between chains.

A–B · 1295 Å² buried · 38 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified, 2 disulfide (artifact, disulfide).

Compared structures

6XZN · Arabidopsis UV-B photoreceptor UVR8 mutant G101S W285A · the same entry in another collection · chain A against A, TM-score 1.00
Q9FN03 · AlphaFold monomer V2.0 prediction for ultraviolet-B receptor UVR8 (Q9FN03) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9FN03
Elsewhere: RCSB PDB 6XZN · PDBe 6XZN · UniProt Q9FN03

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