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Crystal structure of the TOF1-CSM3 complex

Analyse Crystal structure of the TOF1-CSM3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XWX
Type: protein
Length: 1,929 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized PROTEIN,UNCHARACTERIZED protein; Chromosome segregation in meiosis protein
UniProt: G0S825, G0S0S7
Pockets: 20 · best druggability 0.78

Structure

x-ray diffraction · 6 distinct chains · 68% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized PROTEIN,UNCHARACTERIZED protein	protein	564	68% helix, 1% strand	G0S825
B	Chromosome segregation in meiosis protein	protein	84	67% helix, 0% strand	G0S0S7
C	Uncharacterized PROTEIN,UNCHARACTERIZED protein	protein	562	68% helix, 1% strand	G0S825
D	Chromosome segregation in meiosis protein	protein	82	67% helix, 0% strand	G0S0S7
E	Uncharacterized PROTEIN,UNCHARACTERIZED protein	protein	566	69% helix, 1% strand	G0S825
F	Chromosome segregation in meiosis protein	protein	71	52% helix, 0% strand	G0S0S7

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.78	0.93	31	empty
2	324	0.72	0.85	35	empty
3	104	0.71	0.92	27	empty
4	72	0.64	0.91	19	empty
5	288	0.61	0.79	32	empty

Interfaces

6 interfaces between chains.

A–B · 1580 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 1505 Å² buried · 9 hydrogen bonds · protein-protein
E–F · 1311 Å² buried · 4 hydrogen bonds · protein-protein
A–E · 790 Å² buried · 8 hydrogen bonds · protein-protein
C–E · 536 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6XWX · Crystal structure of the Tof1-Csm3 complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S825
Every structure of UniProt G0S0S7
Elsewhere: RCSB PDB 6XWX · PDBe 6XWX · UniProt G0S825 · UniProt G0S0S7

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