Research workbench

EAGT6 TSE6 nt complex

Analyse EAGT6 TSE6 nt complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XRF
Type: protein
Length: 1,002 residues
Chains: 9
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Effector EAGT6; Paar motif family protein
UniProt: Q9I738, A0A2R3IMB8
Pockets: 13 · best druggability 0.81

Structure

x-ray diffraction · 6 distinct chains · 35% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, E	Effector EAGT6	protein	140	21% helix, 49% strand	Q9I738
C	Paar motif family protein	protein	57	74% helix, 0% strand	A0A2R3IMB8
F	Paar motif family protein	protein	56	75% helix, 0% strand	A0A2R3IMB8
G	Effector EAGT6	protein	141	21% helix, 48% strand	Q9I738
H	Effector EAGT6	protein	142	20% helix, 48% strand	Q9I738
I	Paar motif family protein	protein	46	72% helix, 0% strand	A0A2R3IMB8

Pockets

13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	755	0.81	0.85	109	empty
2	135	0.59	0.84	26	empty
3	246	0.56	0.77	28	empty
4	207	0.55	0.79	37	empty
5	210	0.55	0.78	37	empty

Interfaces

18 interfaces between chains.

G–H · 2099 Å² buried · 40 hydrogen bonds · protein-protein
A–B · 2059 Å² buried · 45 hydrogen bonds · protein-protein
D–E · 2029 Å² buried · 40 hydrogen bonds · protein-protein
A–C · 957 Å² buried · 4 hydrogen bonds · protein-protein
D–F · 937 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6XRF · EagT6 Tse6 NT complex · the same entry in another collection · chain I against I, TM-score 1.00
Q9I738 · AlphaFold monomer V2.0 prediction for effector EAGT6 (Q9I738) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I738
Every structure of UniProt A0A2R3IMB8
Elsewhere: RCSB PDB 6XRF · PDBe 6XRF · UniProt Q9I738 · UniProt A0A2R3IMB8

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