Research workbench
Cryo-EM structure of human ZNT8 wt, in the presence of zinc, determined in outward-facing conformation
Analyse Cryo-EM structure of human ZNT8 wt, in the presence of zinc, determined in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XPE
- Type
- protein
- Length
- 554 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc transporter 8
- UniProt
- Q8IWU4
- Ligands
- ZN
- Pockets
- 9 · best druggability 0.66
Structure
electron microscopy · 1 distinct chain · 57% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Zinc transporter 8 | protein | 277 | 57% helix, 7% strand | Q8IWU4 |
Ligands and binding sites
- ZN · Zinc ion · metal · 8 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 473 | 0.66 | 0.77 | 43 | empty |
| 2 | 435 | 0.65 | 0.78 | 44 | empty |
| 3 | 435 | 0.65 | 0.78 | 48 | empty |
| 4 | 300 | 0.64 | 0.81 | 44 | ZN |
| 5 | 324 | 0.62 | 0.79 | 42 | empty |
Interfaces
1 interface between chains.
- B–A · 2577 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 6XPE · Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing… · the same entry in another collection · chain B against B, TM-score 1.00
- Q8IWU4 · AlphaFold monomer V2.0 prediction for zinc transporter 8 (Q8IWU4) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IWU4
- Elsewhere: RCSB PDB 6XPE · PDBe 6XPE · UniProt Q8IWU4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.