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Cryoem structure of human presequence protease in partial close state 2, induced by presequence of citrate synthase

Analyse Cryoem structure of human presequence protease in partial close state 2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XOW
Type: protein
Length: 966 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Presequence protease, mitochondrial
EC: 3.4.24.-
UniProt: Q5JRX3
Pockets: 15 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 47% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Presequence protease, mitochondrial (EC 3.4.24.-)	protein	966	47% helix, 19% strand	Q5JRX3

Pockets

15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	532	0.79	0.85	63	empty
2	915	0.78	0.80	111	empty
3	723	0.77	0.81	77	empty
4	1011	0.76	0.78	94	empty
5	59	0.71	0.97	18	empty

Compared structures

6XOW · CryoEM structure of human presequence protease in partial close state 2, induced by… · the same entry in another collection · chain A against A, TM-score 1.00
Q5JRX3 · AlphaFold monomer V2.0 prediction for presequence protease, mitochondrial (Q5JRX3) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5JRX3
Elsewhere: RCSB PDB 6XOW · PDBe 6XOW · UniProt Q5JRX3

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