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Cryoem structure of human presequence protease in partial open state 2

Analyse Cryoem structure of human presequence protease in partial open state 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XOT
Type: protein
Length: 966 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Presequence protease, mitochondrial
EC: 3.4.24.-
UniProt: Q5JRX3
Pockets: 14 · best druggability 0.75

Structure

electron microscopy · 1 distinct chain · 47% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Presequence protease, mitochondrial (EC 3.4.24.-)	protein	966	47% helix, 20% strand	Q5JRX3

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	507	0.75	0.83	49	empty
2	879	0.74	0.78	79	empty
3	327	0.71	0.84	35	empty
4	370	0.67	0.80	38	empty
5	355	0.67	0.81	43	empty

Compared structures

6XOT · CryoEM structure of human presequence protease in partial open state 2 · the same entry in another collection · chain A against A, TM-score 1.00
Q5JRX3 · AlphaFold monomer V2.0 prediction for presequence protease, mitochondrial (Q5JRX3) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5JRX3
Elsewhere: RCSB PDB 6XOT · PDBe 6XOT · UniProt Q5JRX3

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