Research workbench

C3_CROWN-05

Analyse C3_CROWN-05 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XNS
Type: protein
Length: 1,973 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C3_CROWN-05
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 6 distinct chains · 90% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	C3_CROWN-05	protein	327	91% helix, 0% strand	—
B	C3_CROWN-05	protein	333	91% helix, 0% strand	—
C	C3_CROWN-05	protein	330	91% helix, 0% strand	—
D	C3_CROWN-05	protein	330	91% helix, 0% strand	—
E	C3_CROWN-05	protein	326	90% helix, 0% strand	—
F	C3_CROWN-05	protein	327	90% helix, 0% strand	—

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1044	0.77	0.79	99	empty
2	796	0.72	0.77	81	empty
3	742	0.72	0.78	87	empty
4	699	0.72	0.78	72	empty
5	68	0.71	0.96	19	empty

Interfaces

12 interfaces between chains.

A–C · 1325 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 1263 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 1250 Å² buried · 10 hydrogen bonds · protein-protein
D–F · 1233 Å² buried · 7 hydrogen bonds · protein-protein
D–E · 1190 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6XNS · C3_crown-05 · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6XNS · PDBe 6XNS

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