Research workbench
Sm protein VPS45 in complex with qa snare TLG2 (1-310)
Analyse Sm protein VPS45 in complex with qa snare TLG2 (1-310) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XMD
- Type
- protein
- Length
- 734 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VPS45; TLG2 qa snare
- UniProt
- G0S539, G0SGW7
- Pockets
- 14 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | VPS45 | protein | 556 | 48% helix, 14% strand | G0S539 |
| B | TLG2 qa snare | protein | 178 | 80% helix, 2% strand | G0SGW7 |
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 323 | 0.69 | 0.83 | 44 | empty |
| 2 | 322 | 0.58 | 0.77 | 53 | empty |
| 3 | 174 | 0.51 | 0.78 | 22 | empty |
| 4 | 113 | 0.49 | 0.80 | 18 | empty |
| 5 | 127 | 0.49 | 0.79 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 2803 Ų buried · 48 hydrogen bonds · protein-protein
Compared structures
- 6XMD · SM Protein Vps45 in Complex with Qa SNARE Tlg2 (1-310) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S539
- Every structure of UniProt G0SGW7
- Elsewhere: RCSB PDB 6XMD · PDBe 6XMD · UniProt G0S539 · UniProt G0SGW7
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