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Cryoem structure of mycobacterium tuberculosis zinc metalloprotease ZMP1 in open state

Analyse Cryoem structure of mycobacterium tuberculosis zinc metalloprotease ZMP1 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XLY
Type: protein
Length: 646 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable zinc metalloprotease ZMP1
UniProt: I6X8R2
Ligands: ZN
Pockets: 5 · best druggability 0.72

Structure

electron microscopy · 1 distinct chain · 48% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable zinc metalloprotease ZMP1	protein	646	48% helix, 6% strand	I6X8R2

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	342	0.72	0.84	45	ZN
2	751	0.66	0.74	77	empty
3	192	0.45	0.74	25	empty
4	76	0.31	0.73	19	empty
5	67	0.30	0.74	17	empty

Compared structures

6XLY · Cryoem structure of mycobacterium tuberculosis zinc metalloprotease ZMP1 in open state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6X8R2
Elsewhere: RCSB PDB 6XLY · PDBe 6XLY · UniProt I6X8R2

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