Research workbench

Crystal structure of CA4-activated CARD1(D294N)

Analyse Crystal structure of CA4-activated CARD1(D294N) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XL1
Type: protein + RNA
Length: 750 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CARD1; CA4
UniProt: F2NWD3
Ligands: MN
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CARD1	protein	373	44% helix, 23% strand	F2NWD3
C	CA4	rna	4	—	—

Ligands and binding sites

MN · Manganese (II) ion · metal · 4 copies · chains A, B
EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1021	0.77	0.79	72	empty
2	766	0.69	0.76	100	MN
3	55	0.28	0.74	12	empty

Interfaces

3 interfaces between chains.

A–B · 1773 Å² buried · 26 hydrogen bonds · protein-protein
A–C · 591 Å² buried · 14 hydrogen bonds · protein-nucleic
B–C · 583 Å² buried · 14 hydrogen bonds · protein-nucleic

Compared structures

6XL1 · crystal structure of cA4-activated Card1(D294N) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F2NWD3
Elsewhere: RCSB PDB 6XL1 · PDBe 6XL1 · UniProt F2NWD3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.