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Structure of a mosquito complement inhibitor from anopheles albimanus

Analyse Structure of a mosquito complement inhibitor from anopheles albimanus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XKE
Type: protein
Length: 348 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Albicin
UniProt: A0A1Y9G8D0
Ligands: BR
Pockets: 5 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Albicin	protein	116	72% helix, 2% strand	A0A1Y9G8D0

Ligands and binding sites

BR · Bromide ion · ion · 8 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	408	0.72	0.83	51	BR
2	172	0.58	0.82	25	BR
3	137	0.49	0.79	18	empty
4	145	0.46	0.77	24	BR
5	63	0.32	0.76	12	empty

Interfaces

3 interfaces between chains.

B–C · 700 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 507 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 364 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6XKE · Structure of a mosquito complement inhibitor from Anopheles albimanus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1Y9G8D0
Elsewhere: RCSB PDB 6XKE · PDBe 6XKE · UniProt A0A1Y9G8D0

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