Research workbench
Co-crystal structure of HIV-1 tar RNA in complex with lab-evolved rrm TBP6.7 mutant
Analyse Co-crystal structure of HIV-1 tar RNA in complex with lab-evolved rrm TBP6.7… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XH1
- Type
- protein + RNA
- Length
- 113 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tar binding protein mutant 6.7 Q48R/T50R; Trans-activation response element
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tar binding protein mutant 6.7 Q48R/T50R | protein | 86 | 29% helix, 26% strand | — |
| D | Trans-activation response element | rna | 27 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 196 | 0.44 | 0.74 | 20 | empty |
| 2 | 50 | 0.36 | 0.80 | 14 | empty |
Interfaces
1 interface between chains.
- A–D · 812 Ų buried · 25 hydrogen bonds · protein-nucleic
Compared structures
- 6XH1 · Co-crystal structure of HIV-1 TAR RNA in complex with lab-evolved RRM TBP6.7 mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6XH1 · PDBe 6XH1
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